Handbook of Process Chromatography 2nd Edition: Development, Manufacturing, Validation and Economics

Handbook of Process Chromatography 2nd Edition: Development, Manufacturing, Validation and Economics

This book will update the original edition published in 1997. Since the publication of the first edition, the biotechnology and biologics industries have gained extensive knowledge and experience in downstream processing using chromatography and other technologies associated with recovery and purification unit operations. This book will tie that experience together for the next generation of readers.Updates include:- sources and productivity - types of products made today - experiences in clinical and licensed products - economics - current status of validation - illustrations and tables - automated column packing - automated systemsNew topics include:- the use of disposables - multiproduct versus dedicated production - design principles for chromatography media and filters - ultrafiltration principles and optimization - risk assessments - characterization studies - design space - platform technologies - process analytical technologies (PATs) - biogenerics - comparability assessments.

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Handbook of Fungal Biotechnology, 2nd Edition, Revised and Expanded

Handbook of Fungal Biotechnology, 2nd Edition, Revised and Expanded

The Handbook of Fungal Biotechnology offers the newest developments from the frontiers of fungal biochemical and molecular processes and industrial and semi-industrial applications of fungi. This second edition highlights the need for the integration of a number of scientific disciplines and technologies in modern fungal biotechnology and reigns as the top source on current molecular, biochemical, and medical technologies and commercial usages for fungi. Authored by 81 world-renowned scientists from both industry and academia, it addresses contemporary issues pertaining to intellectual property rights, biodiversity, and biosafety, and devotes an entire section to medical biotechnology.

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Bioreaction Engineering Principles

Bioreaction Engineering Principles

Biotechnology is a rapidly moving field, which builds on the competence and interplay of many different disciplines; biochemistry, microbiology, molecular biology and chemical engineering. The quantitative treatment of biological processes is today a prerequisite for both the design of new bioprocesses and the analysis of cellular function.The present text is an extensively revised edition of the textbook first published in 1994. The quantitative treatment of bioprocesses is a central theme in this book. The book has been restructured to make it more easily accessible to the reader, the material has been updated and several new topics have been added in the text.The focus is on the bioreactor and the processes that occur in the reactor, i.e. the coupling between the reactions occurring in the cell and its environment. The microbial cellular metabolism is the starting point in the treatment. Tools for the quantitative analysis of cellular functions - macroscopic mass balancing, thermodynamics of microbial processes, metabolic network analysis and kinetic modelling - are gradually introduced. After analysis of the cellular reactor, the interaction between the cell and its environment is treated in chapters concerning mass transfer and design of bioprocesses. Finally, the complex subject of scale-up is presented.The book combines, in a rather unique way, a quantitative treatment of physiology at the cellular level with a treatment of the bioreactor and interaction between the cellular reactor and the bioreactor. Many examples and problems are used to illustrate important concepts in the text.

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Transgenic Crops V (Biotechnology in Agriculture and Forestry)

Transgenic Crops V (Biotechnology in Agriculture and Forestry)

Genetic engineering is a powerful tool for crop improvement. The status of crop biotechnology before 2001 was reviewed in Transgenic Crops I-III, but recent advances in plant cell and molecular biology have prompted the need for new volumes.Following Transgenic Crops IV (2007) dealing with cereals, vegetables, root crops, herbs and spices, this volume, Transgenic Crops V, is devoted to fruit, trees and beverage crops. Fruit crops targeted include banana, citrus, mango, papaya, pineapple, watermelon, avocado, grape, melon, apple, Prunus spp., strawberry, and kiwifruit, while trees include walnut, rubber, eucalyptus, tropical tree legumes, Casuarina glauca and conifers. The section on beverage crops reports studies on coffee, cacao, tea, and sugarcane.This volume is an invaluable reference for plant breeders, researchers and graduate students in the fields of plant biotechnology, agronomy, horticulture, forestry, genetics, and both plant cell and molecular biology.

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Flavours and Fragrances: Chemistry, Bioprocessing and Sustainability

Flavours and Fragrances: Chemistry, Bioprocessing and Sustainability

This book is an introduction to the fascinating world of aroma chemicals, essential oils, fragrances and flavour compositions for the food, cosmetics and pharmaceutical industry. The present state-of-the-art technology, the future use of resources and biotechnological approaches for the production of the respective chemical compounds are described. A large section is devoted to the description of the renewable resources of flavours: spice plants, fruits from moderate to tropical climates, vegetables, fermented and heated plants. Analytical methods, such as gas chromatography coupled to human or electronic noses or to a mass spectrometer, are outlined and consumer trends, legal and safety aspects are described. Novel renewable resources come from biotechnology. Enzymes, for example, bio-transform cheap substrates to produce flavours de novo; plant cells in culture may serve as a rich resource of genes coding for metabolic activities in transgenic producers. The book will be of great interest to scientists and engineers in the food, flavour, fragrance and pharmaceutical industries and all respective researchers in academia.

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Bioprocessing for Value-Added Products from Renewable Resources: New Technologies

Bioprocessing for Value-Added Products from Renewable Resources: New Technologies

Bioprocessing for Value-Added Products from Renewable Resources provides a timely review of new and unconventional techniques to manufacture high-value products based on simple biological material. The current source for most chemicals and materials is petroleum. Anticipation of its limited future availability, along with record high prices has spurred interest in alternatives that will be both sustainable and cost-effective.In a very structured way this book begins by describing the modern technologies that form the basis for creating a bio-based industry. Next it lists the various organisms that are suitable for bioprocessing -from bacteria to algae- and it gives their unique characteristics. These first two parts set the stage for a variety of novel, experimental bioprocesses, such as the production of medicinal chemicals, the production of chiral compounds and the design of biofuel cells. Concludes with examples where biological, renewable resources become an important feedstock for large-scale industrial production. Bioprocessing for Value-Added Products from Renewable Resources provides a unique perspective of the industry and the field and serves as an important guide towards the future. The book is suitable for researchers, practitioners, students, and consultants in the bioprocess and biotechnology fields.

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Plant Biotechnology and Transgenic Plants

Plant Biotechnology and Transgenic Plants

Contains case studies illustrating the cell culture production of pigments, flavors, and antineoplastic compounds Plant Biotechnology and Transgenic Plants covers topics that range from food to fragrances to fuel. It includes discussions of technologies and research on the engineering, synthesis, utilization, and control of primary and secondary plant metabolites such as carbohydrates, amino acids, lipids, polymers, proteins, and phytochemicals for industrial, pharmaceutical, and food and feed applications. The editors put the emphasis on recent methods in farming, plant propagation, and breeding and modern procedures to formulate more effective biopharmaceuticals.

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Genetically Engineered Food: Methods and Detection, 2nd Edition

Genetically Engineered Food: Methods and Detection, 2nd Edition

Continuing the very successful first edition, this book reviews the most recent changes to the legal situation in Europe concerning genetically engineered food and labeling. Due to the extremely rapid developments in green biotechnology, all the chapters have been substantially revised and updated. Divided into three distinct parts, the text begins by covering applications and perspectives, including transgenic modification of production traits in farm animals, fermented food production and the production of food additives using filamentous fungi. The second section is devoted to legislation, while the final part examines methods of detection, such as DNA-based methods, and methods for detecting genetic engineering in composed and processed foods.

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Protein Analysis and Purification: Benchtop Techniques

Protein Analysis and Purification: Benchtop Techniques

pass: giga

This comprehensive, practical, and user-friendly manual is designed to be a practical progression of experimental protocols that an inexperienced investigator may follow when embarking on a biochemical or biotechnology project. It will also appeal to experienced researches and graduate students as a benchtop handbook which, without sacrificing scientific concepts, maintains the spirit of experimentation.

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The Biotechnology of Ethanol: Classical and Future Applications

The Biotechnology of Ethanol: Classical and Future Applications

Focusing on the biotechnology of ethanol, this book highlights its industrial relevance as one of the most important products of primary metabolism. The text covers the most advanced developments among classical methods as well as more unconventional techniques, before going on to outline various aspects of new applications and the increasing importance of ethanol as a renewable resource. Topics covered in this unique volume include alternative raw materials, such as municipal waste and waste paper or particular crops, innovative methods of production using genetically engineered microorganisms, and the role of ethanol as both a source of energy and a valuable commodity. The book is a valuable reference in that it combines biotechnological and economic aspects, while also providing an overview of the state of the art in the production and use of ethanol. Throughout, special emphasis has been placed on a balanced presentation between developments in Europe as well as in North and South America. With contributions of T. Senn and H.J. Pieper and of N. Kosaric and F. Vardar-Sukan.

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Handbook of Pharmaceutical Manufacturing Formulations Vol 1-6

Handbook of Pharmaceutical Manufacturing Formulations Vol 1-6

Pharmaceutical formulations remain as much an art today as they have evolved into complex science. With exponential growth of generic formulations, the need for ready formulations has increased. Essentially a cookbook for making drugs, the six-volume handbook contains the recipes and process steps for over 2000 drugs, including a number of biotechnology drugs. This first volume covers tablets, both coated and uncoated and oral powders. The author has painstakingly assembled this book from FDA New Drug Applications, patent applications and the BASF book of generic formulations, all supplemented by his 30-plus years of experience in pharmaceutical formulations.

The first volume in the six-volume Handbook of Pharmaceutical Manufacturing Formulations, Compressed Solid Products covers the largest category of pharmaceutical formulations, compressed solids, which include formulations of tablets and other compressed solids from publicly available but widely dispersed information from FDA New Drug Applications (NDA), patent applications, and other sources of generic and proprietary formulations.

The second volume in the six-volume Handbook of Pharmaceutical Manufacturing Formulations, this book covers uncompressed solids, which include formulations of powders, capsules, powders ready for reconstitution and other similar products from publicly available but widely dispersed information from FDA New Drug Applications (NDA), patent applications, and other sources of generic and proprietary formulations.

The third volume in the six-volume Handbook of Pharmaceutical Manufacturing Formulations, Liquid Products covers liquid drugs, which include formulations of non-sterile drugs administered by any route in the form of solutions (monomeric and multimeric), suspensions (powder and liquid), drops, extracts, elixirs, tinctures, paints, sprays, colloidons, emulsions, aerosols, and other fluid preparations from publicly available but widely dispersed information from FDA New Drug Applications (NDA), patent applications, and other sources of generic and proprietary formulations.

The fourth volume in the six-volume Handbook of Pharmaceutical Manufacturing Formulations, Semi-Solid Products covers semi-solid drugs.

The fifth volume in the six-volume Handbook of Pharmaceutical Manufacturing Formulations, Over the Counter Products includes formulations of products classified by the US FDA under OTC category, from publicly available but widely dispersed information from FDA New Drug Applications (NDA), patent applications, and other sources of generic and proprietary formulations.

The sixth volume in the six-volume Handbook of Pharmaceutical Manufacturing Formulations, Sterile Products covers the sterile products, which include formulations of injections, ophthalmic products and other products labeled as sterile, from publicly available but widely dispersed information from FDA New Drug Applications (NDA), patent applications, and other sources of generic and proprietary formulations.

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